Note: Discussion successfully moved from VMware ESXi 5 to Backup & Recovery
I have been using CBT with NetBackup (and EMC Clariion FC and EqualLogic) for years now, and have never had a single issue with it from the NetBackup side. The time savings on large VMs can be significant, and any time I have spent cleaning up CBT is minimal and usually due to power failures or other unusual circumstances. I wouldn't hesitate at all with it.